Expression and significance of ERK1/2,ER and PR in breast diseases

Objective To investigate the expression and significance of ER,PR,ERK1 and ERK2 in breast diseases.Methods The expression of ER,PR,ERK1 and ERK2 in breast diseases and the relationship among them were detected by the technique of tissue chip and immunohistochemical staining(S-P method) in breast fibroadenoma,adenosis,papilloma in duct and invasive ductal carcinoma.Results The positive ER expression rate in adenosis was the highest,and showed significant difference between fibroadenoma and invasive ductal carcinoma(P0.05).The positive PR expression rate in fibroadenoma was the highest,and showed significant difference between papilloma in duct and invasive ductal carcinoma(P0.05).The positive ERK1and ERK2 expression rates increased in adenosis and invasive ductal carcinoma and the difference was significant when fibroadenoma was compared with adenosis and carcinoma(P0.05).There was a positive correlation between the expression of ERK1 and ERK2(P0.05).Conclusion The high expression rates of ERK1,ERK2 and ER were associated with genesis and progression of adenosis.The positive expression rates of PR in papilloma in duct were low.The high positive expression rates of ER,ERK1,ERK2 and low positive expression rates of PR were significantly associated with carcinoma.These proteins would supply the valuable markers for evaluating the progression and outcome of adenosis and papilloma in duct,and also for directing the therapy of invasive ductal carcinoma.