Expression of CD_64 in Neonatal Infection Disease and Its Clinical Significance

Objective To study CD64 expression in neutrophilic granulocyte and its clinical effect in neonatal infection disease. Methods CD64 was detected among 59 neonatal patients(septicemia group 34 patients, local infection group 25 patients)hospitalized in our neonatal department diagnosed as neonatal infection disease in 48 h after hospitalized,2 weeks after therapy, then the results were compared with 27 patients as non - infection disease during the same period. Results CD64 in septicemia group was (6156. 21±3643. 32) molecula per cell,in local infection group was (2176.19 ± 946. 32)molecula per cell, in non- infection group was (2176. 19 ± 946. 32) molecula per cell.There were significant differences among three groups (all P0. 001). Also the difference between septicemia group and local infection group, septicemia group and non-infection group was significant (all P0. 001). Difference between local infection group and non - infection group was significant(P0.01); When CD64 was detected 2 weeks after therapy,there was no significant difference between septicemia group and local infection group (P0.05). Conclusions CD64 expression increases in bacterium infection disease. It is more obvious in widespread infection desease.and it can be the mark in early diagnosis of neonatal infection disease.