Significance of T-cell subsets detection on the judging of neonatal active cytomegalovirus infection

Objective To investigate the effect of cytomegalovirus(CMV) infection on neonatal cellular immunity,and to provide the basis for the prevention and treatment of CMV infection.Methods All of 38 cases of neonatal cytomegalovirus infection in the hospital were selected,from May 2008 to October 2010.Of which 18 patients had symptoms of infection(Group A),20 patients with no infectious symptoms(Group B),and 20 cases of healthy newborns were selected in the same period(Group C).Venous blood samples of the three groups were collected to detect T-cell subsets.Results CD3+,CD4+ and CD4+/CD8+ of patients in group A were significantly lower than that group B and group C(P0.05),while the difference between group B and group C was not statistically significant(P0.05).CD8+ level of group A was significantly higher than that the group B and group C(P0.05),however the difference between group B and group C was not statistically significant(P0.05).Conclusion The neonatal with symptomatic cytomegalovirus infection showed cellular immune dysfunction,so it is very important to detect T cell subsets of neonatal to discern active cytomegalovirus and guide primary treatment.