Observation of combination of lamivudine and interferon in the treatment of patients with chronic hepatitis B

Objective To observe the effect of combination of lamivudine and interferon in the treatment of patients with chronic hepatitis B.Methods 150 patients with chronic hepatitis B were divided into 3 groups,each group had 50 patients.The patients in combination group received lamivudine and interferonα-2b therapy for one year,the patients in lamivudine group and interferon group received lamivudine and interferonα-2b therapy respectively for one year.Results After one year,the HBV DNA loss and HBeAg/anti-HBe seroconversion in combination group were 86% and 48% respectively,they were higher than in lamivudine group and interferon group(P0.05),YMDD mutations were detected in 1 patients in combination group(2%) but 8 patients in lamivudine group(16%).Conclusion Combination of lamivudine and interferon in the treatment of patients with chronic hepatitis B get a better effect and decrease YMDD mutation.