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2008•Proceeding of Clinical MedicineRequires access

Expression of C-erbB-2 in human breast infiltrating ductal carcinoma and its implication

Zheng Cai-hong

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Abstract

Objective:To investigate the expression of C-erbB-2 protein in breast infiltrating ductal carcinoma and its role in lymph node metastasis.Methods:Use immunohistochemical method(SP method)to detect the expression of C-erbB-2 protein,Estrogen Recepto and Progesterone Receptor in breast cancer.Results:Twenty ceven cases among 60 cases of breast cancer showed positive expression rate was 45.00%.Positive overexpression of C-erbB-2 was significantly different from tumor size,lymph node metastasis and histological grade of breast cancer and it was in negative correlation with ER and PR.Conclusion:The positive expression of C-erbB-2 plays an important role in human breast infiltrating ductal carcinoma and lylmph node metastasis and can become an important index in judging the prognosis of breast cancer.

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What this paper is about

Objective:To investigate the expression of C-erbB-2 protein in breast infiltrating ductal carcinoma and its role in lymph node metastasis.Methods:Use immunohistochemical method(SP method)to detect the expression of C-erbB-2 protein,Estrogen Recepto and Progesterone Receptor in breast cancer.Results:Twenty ceven cases among 60 cases of breast cancer showed positive expression rate was 45.00%.Positive overexpression of C-erbB-2 was significantly different from tumor size,lymph node metastasis and histological grade of breast cancer and it was in negative correlation with ER and PR.Conclusion:The positive expression of C-erbB-2 plays an important role in human breast infiltrating ductal carcinoma and lylmph node metastasis and can become an important index in judging the prognosis of breast cancer.

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Available abstract

Objective:To investigate the expression of C-erbB-2 protein in breast infiltrating ductal carcinoma and its role in lymph node metastasis.Methods:Use immunohistochemical method(SP method)to detect the expression of C-erbB-2 protein,Estrogen Recepto and Progesterone Receptor in breast cancer.Results:Twenty ceven cases among 60 cases of breast cancer showed positive expression rate was 45.00%.Positive overexpression of C-erbB-2 was significantly different from tumor size,lymph node metastasis and histological grade of breast cancer and it was in negative correlation with ER and PR.Conclusion:The positive expression of C-erbB-2 plays an important role in human breast infiltrating ductal carcinoma and lylmph node metastasis and can become an important index in judging the prognosis of breast cancer.

Key concepts: Breast cancer, Immunohistochemistry, Medicine, Estrogen receptor, Breast carcinoma, Ductal carcinoma, Metastasis, Oncology

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Expression of C-erbB-2 in human breast infiltrating ductal carcinoma and its implication — Research Paper | ScholarLens