Comparative Study on Risperidone Combined Clozapine and Risperidone in the Treatment of Refractory Schizophrenia

Objective To compare the efficacy and safety of clozapine combined with risperidone in the treatment of refractory schizophrenia.Methods 63 cases were divided into two groups randomly,32 cases of treatment-refractory schizophrenia were treated with risperidone combined clozapine(the treatment group) and 31 cases were treated with risperidone(the control group).The clinical effect of patients were measured with positive and negative symptoms scale(PANSS),and side effects were assessed with treatment emergent symptoms scale(TESS)respectively before and after 4,8,12 week treatment.Results There were significant differences in the curative effect between the two groups(P0.05).After eight weeks treatment,total score of PANSS in two groups were much lower than before,the treatment group had greater decreases.After twelve weeks treatment,total score of PANSS in the treatment group was lower than that in the control group.There were statistical differences between the two groups(P0.05).Conclusion Clozapine combined with risperidone has curative effect affirmation to treat TRS,this deserves utilization in the clinical area.