A Clinical Control Study on Effects of Clozapine with Risperidone on Refractory Schizophrenia

Objective To explore the curative effect and safety of Risperidone with Clozapine in the treatment of refractory schizophrenia,and to provide the basis for clinical medication.Methods The 76 patients with refractory schizophrenia were randomly divided into the study group(36 cases) and the control group(40 cases),the study group was treated by Risperidone and Clozapine,while the control group by Risperidone alone.The curative effect and side effect were evaluated by BPRS and TESS at the time points: before treatment,4,8 and 12 weeks after the treatment.Results The BPRS total scores of the study group were obviously lower than that of the control group at the end of the fourth week,eighth week and twelfth week.The TESS total scores between the two groups had no significant difference(P0.05);The side effect such as salivation,sleepiness,white blood cell reduction were obviously higher in the study group than as compared to the control group,but it's well tolerated.Conclusion The combination of Clozapine and Risperidone for the refractory schizophrenia can shorten the response latency in the treatment,it is effective and safe.