Correlation analysis of IL-33 level and multiple myeloma

Objective To detect serum IL-33 level of multiple myeloma patients,and to explore the correlation between IL-33 level and multiple myeloma. Methods From Jan 2012-Jan 2013,37 cases of multiple myeloma( MM) patients and 50 cases of healthy controls were assigned as the research objects,ELISA method used to detecte serum levels of IL-33 of all the objects. Data were analyzed using method of statistics. Results IL-33 detection rate of two groups had no significant difference,but IL-33 level of MM patients decreased significantly compared with healthy controls( P 0. 05),and IL-33 level of MM had been shown to negatively correlate with MM stage. Conclusions IL-33 levels may be decreased by adjusting the cellular immunity to promote the progress of MM. Maintaining the balance of T cell subgroup may contribute to the treatment of myeloma disease.