THE EFFECTS OF XUEBIJING INJECTION ON ACUTE LUNG INJURY IN RATS

[Objective]To discuss the effects on acute lung injury induced by intestinal ischemia-reperfusion of Xuebijing injection and its potential mechanism.[Methods]36 adult male Wistar rats were randomly divided into 3 groups:Sham operation control group(C),ischemia-reperfusion group(I/R)and I/R+Xuebijing injection group(XBJ),12 animals in each group.Acute lung injury rat model was established by intestinal ischemia-reperfusion.The pathological change of lung tissue,the level of malondialdehyde(MDA),activity of myeloperoxidase(MPO),the mRNA levels of TNF-α,IL-1β,IL-6 in every group were measured.[Results]In I/R group,alveolar wall thickened,a great of polymorphonuclear neutrophil infiltrated into interstitial tissue of lung,MDA level and MPO activity of lung tissue arose significantly,the TNF-α,IL-1β,IL-6 mRNA levels were higher than control group,while in XBJ group,all above parameters were lower than I/R group.[Conclusion]Xuebijing injection could reduce acute lung injury induced by intestinal ischemia-reperfusion in rats,and the mechanism may be associated with down-regulating cytokine levels such as TNF-α,IL-1β,IL-6.