Protective Effects of Xuebijing Injection on Lung Injury in Rats With Sepsis

Objective:To investigate the protective effects and mechanisms of the integrated traditional Chinese medicine Xuebijing injection on lung injury of rats with sepsis.Methods:Sepsis was established in rats by cecum ligation and puncture(CLP).Eighty male Wistar rats were randomly divided into normal control group(group N,n=8),sham operation group(group S,n=8),CLP model group(group C,n=32),Xuebijing treated group(group X,n=32).Rats in group C and X were given normal saline or Xuebijing injection with a dose of 2 ml/kg intravenously after CLP models were established respectively.Then 8 rats were sacrificed at 3,6,12,and 24 hours after CLP.The lungs were removed for detecting malondialdehyde(MDA)and myeloperoxidase(MPO);serum tumor necrosis factor alpha(TNF-α)was also examined.Results:The rats with sepsis demonstrated an increase in MDA,MPO activity of the lung tissue and TNF-α activity of serum.In contrast,the rats after Xuebijing injection treatment exhibited a significant lowering in MDA,MPO and TNF-α activity.Conclusions:Xuebijing injection treatment might ameliorated lung injury by down-regulating the expressions of MDA,MPO and serum TNF-α.