Application Research on skin expander in the treatment of epidermal growth factor into

Objective Recombinant human epidermal growth factor(rhEGF) on the clinical effect of application of intraoperative skin expansion. Methods 38 patients were treated with 76 expanders, were randomly divided into treatment group(36 expanders) and control group(36 expanders). The treatment group in the conventional expansion at the same time,the expansion of the skin on the surface of rhEGF and massage into use import massage instrument.The control group was only routine expansion. Measuring two groups rated capacity expansion caused by the time required, the skin soft tissue expansion rate and the immediate retraction rate,using self controlled method for comparative analysis. The content of collagen, type I/III collagen ratio(%) were measured and the pathological sections. Results At the same time rhEGF therapy can make the expansion to the rated capacity and shorten the time of water injection,immediate retraction rate compared with the control group decreased, the skin expansion rate increased, effectively reduce the immediate retraction rate of skin flap. The treatment group of coarse and dense bundles of collagen, type I/III collagen ratio decreased. Conclusion While rhEGF into treatment can shorten the injection duration when water, accelerate the expansion of skin, reduce skin flap retraction rate, improve skin flap quality, improve the effect of treatment.