Application of recombinant human epidermal growth factor gel in nursing of stage III bed sore

Objective To observe the effect of recombinant human epidermal growth factor(rhEGF)gel in combination with infrared radiation on the treatment of stage Ⅲ bed sore.Methods Thirty-eight patients with bed sore were recruited and divided into two groups:the rhEGF treatment group and control group.The rhEGF treatment group was given rbEGF gel on the surface of ulcers,and the ulcers in the control group were washed with 3% hydrogen peroxide.The treatment effect of the two groups was compared by observing the wound healing rate,histological changes,the hydroxyproline content,and the ratio of type Ⅰ/Ⅲ collagen. Results The wound in rhEGF treated group healed faster than in control group.The average healing time of stage Ⅲ bed sore was(10±2.5)d in rhEGF treated group and(35±8.7)d(P0.01)in control group.At d 3,6,and 9 after treatment,more granulation tissue cells and blood vessels appeared in the wounds in rhEGF treatment groups than in control group.The HYP content increased and the ratio of type Ⅰ/Ⅲ collagen decreased in rhEGF treatment group.Conclusion The application of rhEGF to pressure sore shortens the wound healing time,improves HYP content and decreases the ratio of type Ⅰ/Ⅲ collagen,rhEGF can promote wound surface healing.