Pharmacokinetics and in vitro-in vivo Correlation of Ibuprofen Sustained-release Pellet-fi lled Capsules in Beagle Dogs

The pharmacokinetics of ibuprofen sustained-release pellet-filled capsules(test preparation) in Beagle dogs was investigated with Fenbid capsules as the reference preparation. The main parameters of test and reference preparations were as follows: t 1/2(4.14±1.12) and(3.84±0.77)h, c max(81.30±24.52) and(88.81±16.87)?g/ml, AUC 0→t(420.79±96.17) and(410.10±85.06)?g·h·ml-1, respectively. The self-made product showed a good sustained-release behavior and its relative bioavailability was(104.70±27.86)%. There was a significant correlation between in vitro release and in vivo absorption.