ScholarLens Back to search
2009•Chinese Journal of New Clinical MedicineRequires access

Expression and significance of IGF-I and IGF-IR in different part of keloid

Wei Haiming

Open publisher page 0 citations

Abstract

Objective To explore the aggressive growth characteristics in peripheral parts and central parts of keloid by analysing the insulin-like growth factor-I(IGF-I)and the insulin-like growth factor-I receptor(IGF-IR)index.Methods Fibroblasts of 8 keloids cases and 4 normal skin cases were investigated by immunohistochemical analysis of IGF-I and IGF-IR.IGF-I and IGF-IR index of difference parts in keloids and normal skin were compared.Results These were no positive fibroblasts in normal skin samples.The IGF-I and IGF-IR index of peripheral parts of keloids are higher than those of central parts,and there is significant difference(P0.05).Conclusion The difference in distribution of IGF-I and IGF-IR index may be responsible for the aggressive growth of keloid.

About this research paper

What this paper is about

Objective To explore the aggressive growth characteristics in peripheral parts and central parts of keloid by analysing the insulin-like growth factor-I(IGF-I)and the insulin-like growth factor-I receptor(IGF-IR)index.Methods Fibroblasts of 8 keloids cases and 4 normal skin cases were investigated by immunohistochemical analysis of IGF-I and IGF-IR.IGF-I and IGF-IR index of difference parts in keloids and normal skin were compared.Results These were no positive fibroblasts in normal skin samples.The IGF-I and IGF-IR index of peripheral parts of keloids are higher than those of central parts,and there is significant difference(P0.05).Conclusion The difference in distribution of IGF-I and IGF-IR index may be responsible for the aggressive growth of keloid.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To explore the aggressive growth characteristics in peripheral parts and central parts of keloid by analysing the insulin-like growth factor-I(IGF-I)and the insulin-like growth factor-I receptor(IGF-IR)index.Methods Fibroblasts of 8 keloids cases and 4 normal skin cases were investigated by immunohistochemical analysis of IGF-I and IGF-IR.IGF-I and IGF-IR index of difference parts in keloids and normal skin were compared.Results These were no positive fibroblasts in normal skin samples.The IGF-I and IGF-IR index of peripheral parts of keloids are higher than those of central parts,and there is significant difference(P0.05).Conclusion The difference in distribution of IGF-I and IGF-IR index may be responsible for the aggressive growth of keloid.

Key concepts: Keloid, Medicine, Immunohistochemistry, Growth factor, Significant difference, Insulin-like growth factor, Peripheral, Transforming growth factor

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Expression and significance of IGF-I and IGF-IR in different part of keloid — Research Paper | ScholarLens