2005•Yaowu fenxi zazhiRequires access

Determination of Notoginsenoside R_1 and Ginsenoside Rg_1, Rb_1 in Xueseitong Tablets by RP-HPLC Gradient Elution Method

Zhu Wei-quan

Abstract

Objective:A new HPLC gradient elution was studied for the determination of notoginsenoside R_1, ginsenoside Rg_1 and Rb_1 in Xuesaitong tablets.Methods:Eclipse XDB-C_8 column was used with a mobile phase of acetonitrile-water 0-15 min (25:75-32:68) gradient elution, pose time was 5 min; the wavelength of detecter was set at 203 nm.Results:The linear range of notoginsenoside R_1,ginsenoside Rb_1 and Rg_1 was 0.51-3.05,1.68 -10.09 and 2.73-16.39 μg, respectively, the average recovery rate was 99.92% (RSD= 0.70%),98.93% (RSD =1.4%) and 102.8 % (RSD= 0.81%), respectively.Conclusion:The method is rapid, accurate, sensitive and reliable.The results show that the method can be used to control quality of products.

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Key concepts: Chemistry, Gradient elution, Chromatography, Ginsenoside, High-performance liquid chromatography, Elution, Acetonitrile, Ginsenoside Rg1