Study on the pharmacokinetics of cefquinome sulfate injection in swine.

The pharmacokinetics and bioequivalence of cefquinome sulfate injection in swine were investigated.The testing drug was cefquinome sulfate injection which was made by Zhejiang Hai zheng Animal Pharmaceutical Company,and the control drug was also cefquinome sul fate injection which was made by Intervet Company.The experiment was carried out by using a cross-over method with random two gro ups and two-period and the test drugs of two groups were interchanged at the se cond period.The drug concentration-time data of both groups,processed by 3P97 S oftware,were fitted most suitably with two-compartment open model.The main para meters for the testing and control drugs(2 mg/kg)were as follows:the half life of distribution phase was 0.315 h and 0.476 h,respectively.The half life of elimination phase was 1.429 h and 1.444 h,respectively.Areas under curve was 12.342(μg/mL)·h and 13.745(μg/mL)·h,respectively.Bioequivalence analysis for the parameters AUC was performed by the 3P97 Software.The 90% of confidence interval of AUC for bioequivalence analy sis was 82.1% to 100.2%,within the required range of the Ministry of Agriculture of the People's Republic of China(80% to 120%),indicating that the testing dru g and control drug were bioequivalent in pharmacokinetics.