Desloratadine combined with BCG polysaccharide and nucleic acid in treating 62 patients with chronic urticaria

AIM To investigate the efficacy of combining desloratadine and BCG polysaccharide and nucleic acid injection in treating chronic urticaria.METHODS One hundred and twenty-four patients with chronic urticaria were divided into two groups(62 in each).The patients in the control group were given desloratadine 5 mg oral once a day for 28 days.And the patients in the treatment group were treated with desloratadine 5 mg.d-1 and BCG polysaccharide and nucleic acid injection 2 mL every other day for 28 days.The clinical efficacy and the adverse reactions in both groups were observed.RESULTS The cure rate of the treatment group was 94%,and 63% of the control group(P 0.05).There were significant differences in clinical efficacy between two groups(P 0.05).The relapse rate of cured patients in the treatment group was 9%(5/58),significantly lower than that in the control group(41%,16/39,P 0.05).No serious adverse reactions occurred in each group.CONCLUSION Desloratadine combined with BCG polysaccharide and nucleic acid injection in treating chronic urticaria is superior to using desloratadine only.