Association between PAI-2 gene polymorphism and coronary heart disease

Objective:To study the allele frequencies and genotype distribution of the PAI-2 gene in Chinese patients with coronary heart disease(CHD),and analyze the association between the PAI-2 gene polymorphism and CHD.Methods:The polymorphism of the PAI-2 gene was analyzed by the polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) in 57 patients with CHD and familial history and 62 healthy controls without CHD or familial history to research into the influence of the gene polymorphism on CHD.Results:The distribution of the PAI-2 gene Ser/Cys413 15588 G/C polymorphism was significantly different between the CHD group and the control group(P0.05).The allele frequencies distribution between the 2 groups was also different(P0.05).The relative risks of different genotypes for CHD were: CC was a risk factor for CHD(OR =2.405,95%CI:1.059～5.667),GG was a protective factor for CHD(OR =0.303,95% CI: 0.089～1.029).The relative risk in C allele carriers was 28.88 times as high as that in G allele carriers(OR =28.88,95% CI: 1.96～437.62).Conclusions:The PAI-2 gene Ser/Cys413 15588 G/C polymorphism is associated with CHD,the C allele is a risk factor for CHD and the G allele is a protective factor for CHD.