Perioperative Use of Prophylactic Antibiotics before and after Intervention in Patients Undergoing Type II Incision Operation

OBJECTIVE:To investigate the antibiotic use before and after intervention in 400 cases from Tianjin Municipal First Central Hospital and familiarize the Notice on Issues Related to the Management of Clinical Use of Antibiotics issued by the general office of ministry of health(Notice in short) and find out the difference of drug use before and after the issuing of the notice and strengthen and standardize the rationality in the use of prophylactic antibiotics for patients undergoing type II incision operation.METHODS:The medical records of a total of 400 patients undergoing type II incision operation who had been discharged from our hospital during Mar.,June,Sept.and Dec.from 2007 to 2010 were randomly selected for control study by dividing them into intervention group(200 cases collected after intervention,i.e.from 2009 to 2010) and non-intervention group(200 cases before intervention,i.e.from 2007 to 2008).A statistical analysis was performed on patients' age and sex,days of hospital stay,cost of hospitalization,cost of antibiotics,choice of drugs and drug combination etc.RESULTS:Significant differences were noted between the intervention group and the non-intervention group with regard to the rationality in preoperative and postoperative antibiotic use(P0.01,P0.05).The intervention group had significant lower rate of combination use of prophylactic antibiotics(P0.05);there were no differences between the two groups in the change of body temperature(P0.05);the intervention group had significantly shorter hospital stay than in the non-intervention group(P0.05);there were no statistical differences between the two groups in the costs for antibiotics(P0.05).CONCLUSION:After intervention,the irrational use of prophylactic antibiotics for patients undergoing type II incision operation become significantly less frequent,and medical workers have attached greater importance to the use of antibiotics.The intervention is of great importance to further standardizing rational use of antibiotics and reducing the occurrence of bacterial drug resistance.