Combination of Lansoprazole Famotidine and Mosapride in Treatment of Gastroesophageal Reflux Disease

Objective To evaluate clinical effects of lansoprazole, famotidine and mosapride on the treatment of gastro-esophageal reflux disease (GERD). Methods 46 patients with GERD were randomly treated with a combination of lansoprazole, famotidine and mosapride or with ranitidine alone. Clinical effects and inflammatory lesions in lower esophagus were analyzed 4 weeks after systemic treatment. Results Clinical symptoms including acid regurgitation, heartburn, retrosternal pain were significantly relieved 4 weeks after systemic treatment. Inflammatory lesions in lower esophagus were also markedly improved (P 0.05). Conclusion A combination of lansoprazole, famotidine and mosapride is an effective way to treat GERD.