Expression and relationship of CB、MMP-2 in epithelial ovarian carcinoma

Objective:To study the expression and relationship of CB and MMP-2 in epithelial ovarian carcinoma.Methods:Immunohistochemical staining S-P method was used to detect the expression of CB and MMP-2 in 60 cases of epithelial ovarian carcinoma,20 cases of benign ovarian tissue,20 cases of borderline ovarian tumor and 10 cases of normal ovarian tissue.Results:The expression level of CB and MMP-2 was obviously increased ( P 0.001) in normal ovarian tissue,borderline ovarian tumor and epithelial ovarian carcinoma.The expressions of CB and MMP-2 were in positive correlation with tumor grade and lymphatic metastasis.,while no correlation with tumor stage and histological grading.There was significant positive correlation between CB and MMP-2 in epithelial ovarian carcinoma.Conclusion:The increased expression of CB and MMP-2 may play an important role in the process of carcinogenesis,progression and differentiation of epithelial ovarian carcinoma.CB and MMP-2 may be useful targets for treatment of ovarian carcinoma.