Study on dissolution determination method and dissolution rate of Xindakang Sugar-coated Tablets in vitro

Objective: To establish the method of dissolution determination for evaluating and improving the quality of Xindakang sugar coated Tablets. Xindakang Sugar coated Tablets from three enterprises were investigated. Methods: To adopt 900mL0.5% Tween80 H 2O as dissolvent and rotating basket method at 100r·min -1 , the cumulative dissolution percentage was determined by UV. The dissolution parameters was obtained by Weibull distribution model and dealed with one way ANOVA. Results: The significant differences in dissolution parameters(T d, T 50 ,m)( P 0.01)of the three samples Xindakang Sugar coated Tablets were discovered by statistical analysis. Conclusion: The method established is suitable and feasible for the dissolution determination of Xindakang sugar coated tablets. It will be necessary to bring the dissolution determination method into the quality control standard for improving the quality and preparation technology of Xindakang Sugar coated Tablets.