The Effect Observation of Escitalopram Combined with Olanzapine in the Treatment of Depression Disorder

Objective To observe the clinical effects and safety of using escitalopram combined with olanzapine in the treatment of depression disorder.Methods 80 cases of patients with depression disorder as studied object,and randomly divided them into observation group and control group,40 cases in each group.Control group was treated with escitalopram for 12 weeks;while observation group was treated with escitalopram combined with olanzapine for 12 weeks.The efficacy and side effects were evaluated with Hamilton Depression Rating Scale(HAMD) and Treatment Emergent Symptom Scale(TESS) after the treatment.Results Scores of HAMD in two groups both decreased significantly(P0.05) after the treatment.Scores of HAMD in observation group were significantly lower than that in control group at the 8th and 12th weekend(P0.05).There is no serious side-effect that happened in two groups,and the side-effect rates in two groups have no significant difference(P0.05).Conclusion Escitalopram combined with olanzapine has better effect than escitalopram monotherapy in the treatment of depression disorder with satisfactory tolerability.SO it deserves to apply and prompt it on clinical work.