Effects of Tiotropium and Seretid on Pulmonary Function in Patients with Chronic Obstructive Pulmonary Disease

Objective:To observe the effects of tiotropium and seretid on pulmonary function in patients with chronic obstructive pulmonary disease (COPD). Methods:Forty patients with COPD were randomly divided into two groups (n=20 for each group),seretide (control group) and tiotropium bromide (experimental group). All patients were treated with routine anti-infection,?oxygen inhalation, relieving phlegm and anti asthma. The patients in experimental group inhaled tiotropium and seretid simultaneously, and patients in control group inhaled seretide. Patients in the two groups continued the treatment discharge. The fellow-up period was 12 weeks. The pulmonary functions were detected before treatment and 12 weeks after discharge in patients of two groups. Results:There were no significant differences in the values of forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), FEV1/FVC,FEV1%,arterial partial pressure of oxygen [p(O2)] and partial pressure of carbon dioxide [p(CO2)] before treatment between two groups (P 0.05). But these were significantly improved after treatment in patients of experimental group than those of control group (P 0.05). Conclusion:Seretid combined with tiotropium can significantly improve the pulmonary functions in patients with COPD.