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Determination of Notoginsenoside R1 in Xinling Pills by HPLC

Zhu Ji-shi

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Abstract

Objective To establish a HPLC method for the content determination of Notoginsenoside R1 in Xinling pills. Methods The analysis was performed on a Agilent Hypersil ODS, using the mixture of acetonitrile (A) and water (B) as the mobile phase. Elution was performed using a gradient mode (0 min: 19% A→12 min: 19% A→60 min: 36% A), and the flow rate was 1.0 ml/ min. The detection wavelength was 203 nm. Results There was good linearity in the range of 8.304～249.120 g/ml for Notoginsenoside R1, r=0.9998. The average recovery and RSD were 99.5% and 1.2% for Notoginsenoside R1. Conclusion This method is simple and reliable for the quality control of Xinling pills.

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What this paper is about

Objective To establish a HPLC method for the content determination of Notoginsenoside R1 in Xinling pills. Methods The analysis was performed on a Agilent Hypersil ODS, using the mixture of acetonitrile (A) and water (B) as the mobile phase. Elution was performed using a gradient mode (0 min: 19% A→12 min: 19% A→60 min: 36% A), and the flow rate was 1.0 ml/ min. The detection wavelength was 203 nm. Results There was good linearity in the range of 8.304～249.120 g/ml for Notoginsenoside R1, r=0.9998. The average recovery and RSD were 99.5% and 1.2% for Notoginsenoside R1. Conclusion This method is simple and reliable for the quality control of Xinling pills.

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Available abstract

Objective To establish a HPLC method for the content determination of Notoginsenoside R1 in Xinling pills. Methods The analysis was performed on a Agilent Hypersil ODS, using the mixture of acetonitrile (A) and water (B) as the mobile phase. Elution was performed using a gradient mode (0 min: 19% A→12 min: 19% A→60 min: 36% A), and the flow rate was 1.0 ml/ min. The detection wavelength was 203 nm. Results There was good linearity in the range of 8.304～249.120 g/ml for Notoginsenoside R1, r=0.9998. The average recovery and RSD were 99.5% and 1.2% for Notoginsenoside R1. Conclusion This method is simple and reliable for the quality control of Xinling pills.

Key concepts: Chromatography, High-performance liquid chromatography, Gradient elution, Pill, Chemistry, Acetonitrile, Content determination, Pharmacology

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