Effects of Guanshu drop pills on blood rheology and blood gas analysis in rat model with acute blood stasis

OBJECTIVE To observe the effects of Guanshu drop pills on blood rheolog and blood gas analysis in rat model with acute blood stasis,for offering the accordance for research on the anti-aging action of Guanshu drop pills.METHODS The acute blood stasis model rats were made by injection of adrenaline repeatedly and soaked ice water.Rats were divided into 6 groups,i.e.normal control group,model group,compound Danshen tablet group and Guanshu drop pills high-dose,medium-dose and low-dose groups.Hemorheology and blood gas analysis parameters of rats were determined and analyzed.RESULTS Guanshu drop pills could markedly decrease the whole blood viscosity,blood reduction viscosity,plasma viscosity,erythrocyte conglomeration index,hematocrit and partial pressure of carbon dioxide;it could also rise the erythrocyte deformation index,hemoglobin,oxyhemoglobin,partial pressure of oxygen and saturation of blood oxygen.CONCLUSION Guanshu drop pills can markedly ameliorate the hemorheology which were abnormal augmentation in acute blood-stasis model rats,prevent the increase of blood viscosity,improve the blood rheology and increase amount of oxygen in the blood.It has the function of anti-aging by increasing the blood and oxygen supply for the tissues and organs.