Clinical significance of the expression of surviving in squamous cell of carcinoma of larynx.

Objective To explore the expression of Survivin in squamous cell carcinoma of larynx and its relationship with histopathological factors. Methods The expressions of Survivin in laryngeal cancer of 45 cases and normal laryngeal tissues of 7 cases were studied by immunohistochemical S - P staining. Results It was found that the positive rate of Survivin in 45 cases of laryngeal squamous cell carcinoma was 62.2 % (28/45 ) . In contrast, 7 cases of normal laryngeal epithelium did not express Survivin. The positive rate in the clinical stage Ⅲ-Ⅳ of these patients was higher than the clinical stage Ⅰ-Ⅱ(P 0.01). The positive rate in the medial and low differentiation of these patients was higher than the high differentiation ( P 0.01) . The positive rate in those carcinoma with cervical lymph node metastasis was higher than those without cervical lymph node metastasis (P 0.01). Conclusion The expression of Survivin was related to the clinical stage, histological grade and cervical lymph node metastasis of la-ryngeal cancer, the high expression of Survivin may play an important role in the formation and metastasis of laryngeal cancer.