VEGF expression of cancer cells related to prognosis of patients with gastric cancer

[Objective] To explore the relationship of VEGF expression and prognosis and MVD to clinical pathological parameters and prognosis of patients with gastric cancer.[Methods] Immunohistochemistry was used to detect expressions of VEGF,CD34 in 64 gastric cancers and 20 surrounding tissues,and micro-vessel density(MVD) was accounted.[Results] VEGF expression rate in gastric cancers and surrounding tissue were 54.1% and 29.7%(P0.05).The rates in the groups with and without lymph node metastasis were 65.8% and(42.3%)(P0.05);the rates in the groups with without serous infiltration were 61.5% and 36%;The rates in the groups with less 5 years of survival period and more than 5 years were 70.6% and 25.0%.MVD in gastric cancer and surrounding tissue were 35.32±12.29 and 18.37±12.35.The rates in the groups with and without lymph node metastasis were 60.22±10.37 and 41.74±8.91;The rates in the groups with and without serous infiltration were 58.32±12.22 and 41.13±5.29.MVD was 30.91±12.22 and 22.78±10.84 in VEGF positive and negative expression groups of gastric cancer,respective(P0.05).[Conclusion] The progressing vessels generation of VEGF expression might relate to poor prognosis of patients with gastric cancer.