CT perfusion : the clinical application in the diagnosis of breast diseases

Objective To assess the CT perfusion characteristics of breast diseases. Methods Twenty-two patients with fibroadenoma accompanied with cyst (n=1), other benign diseases (n=5), and carcinomas (n=16) underwent breast CT scan. CT perfusion was performed for breast with cine mode (0.5 s per rotation ) on a multislice CT scanner ,120 kV, 60 mA, 4×5 mm collimation. Contrast injection was done by using 50 ml nonionic contrast agent ( 300 mg I/ml ), at a flow rate of 4 ml/s with a power injector, 5 seconds delay, and data acquisition lasted for 50 seconds. These data were processed on a GE AW 4.1 workstation using perfusion 3 software package, and the mean BF, BV, MTT and PS were measured and statistically analyzed. Results The mean BF, BV, MTT and PS in carcinoma were (33.55± 28.40) ml·min -1 · 100 g -1 , (5.60±3.08) ml/100 g, (15.37±6.41) s, (18.71±10.42) ml·min -1 ·100 g -1 . The mean BF, BV, MTT and PS in contralateral normal breast of carcinoma were (10.36±9.44) ml·min -1 · 100 g -1 , (0.70±0.22) ml/100 g, (13.55±7.27) s, (1.54±1.74) ml·min -1 ·100 g -1 . The mean BF, BV, and PS between carcinoma and normal breast were statistically significant (P 0.05), and the mean MTT was not statistically significant (P0.05). The mean BF, BV, MTT and PS in fibroadenoma were (62.57±19.62) ml·min -1 ·100 g -1 , (7.37±1.30) ml/100 g, (11.24±3.34) s, (27.63±3.87) ml·min -1 ·100 g -1 . The mean PS between carcinoma and fibroadenoma was statistically significant (P0.05), and the mean BF, BV, and MTT were not statistically significant (P0.05). The mean BF, BV, MTT and PS in benign lesion were (7.65±10.24) ml·min -1 ·100 g -1 , (1.23±0.97) ml/100 g, (14.94±10.68) s, (1.81±1.72) ml·min -1 ·100 g -1 . The mean BF, BV, and PS between carcinoma and benign lesion were statistically significant (P0.05), and the mean MTT was not statistically significant (P0.05). Conclusion MSCT perfusion may reflect the features of breast diseases, and provide valuable hemodynamic message. These parameters have a value in diagnosis of breast diseases and are helpful for differential diagnosis.