The Application of Multi-slice Spiral CT Perfusion in Diagnosis of Thyroid Disease

Objective To investigate the technique of Multi-slice Spiral CT perfusion with body tumor software package and evaluate its value in diagnosing thyroid disease.Methods Patients with normal thyroid(n=21),thyroid carcinoma(n=32),and benign thyroid disease(n=69),including thyroid adenoma in 31cases and nodule goiter in 38 cases,were studied by perfusion MSCT.The parameters of CT perfusion such as blood flow(BF),blood volume(BV),mean transit time(MTT),and permeability surface(PS)were measured by Perfusion 2 software package(GE) with deconvolution method and statistically analyzed.Results The mean BF,BV,MTT,and PS in normal thyroid tissue were(549.61±187.91)mL·100 g-1·min-1、(9.34±3.41)mL/100 g、(2.65±0.97)s、(36.07±25.11) mL·100 g-1·min-1,respectively.The mean BF,BV,MTT,and PS in thyroid carcinoma were(326.81±139.14)mL·100 g-1·min-1、(7.95±5.65)mL/100 g、(3.90±2.60)s、(54.06±22.95)mL·100 g-1·min-1,respectively.The mean BF,BV,MTT,and PS in benign group were(330.53±144.02)mL·100 g-1·min-1、(8.14±5.33)mL/100 g、(3.87±2.56)s、(41.84±24.54)mL·100 g-1·min-1,respectively.The mean BF and PS among three groups had significant differences(P=0.001,0.018).However,statistically,the mean BV and MTT were not significantly different(P=0.586,0.093).The differences of BF were statistically significant between the malignant group and the group with normal thyroid,and between the benign group and the group with normal thyroid(P=0.000,0.001).There was not statistically significant difference between malignant group and benign group(P=1.000).The differences of PS were statistically significant between the malignant group and the group with normal thyroid,between malignant group and benign group(P=0.009,0.020),and PS between the benign group and the group with normal thyroid had not significant difference(P=0.341).Conclusion Perfusion parameter of PS is valuable for the differentiation of benignancy from malignancy in thyroid to a certain extent.