Distribution and changes of the antibiotic resistance of Pseudomonas aeruginosa from 2008 to 2010

Objective To investigate the clinical distribution and the change in drug resistance of Pseudomonas aeruginosa in our hospital,in order to provide the basis for rational use of drugs.Methods All kinds of samples from inpatient department from January 2008 to December 2010 were cultured,bacteria were identified by VITEK-2 compact automated microbiology system.The drug-sensitivity testing was performed to 13 antimicrobial agents by K-B methods.Results Among the 865 strains of Pseudomonas aeruginosa,the pathogens isolated from respiratory tract specimens were predominate(80.8%),the main departments with hospital infection caused by Pseudomonas aeruginosa were senior officials inpatient ward,tumour department,neurology department and pneumology department.The drug resistance of Pseudomonas aeruginosa against 13 kinds of drugs all appeared an increasing trend year by year.The antibacterial activity of Amikacin and Imipenem to Pseudomonas aeruginosa were superior,with average resistance rates as 13.8% and 13.4%,which could be the first-chosen antibiotic for severe infection of Pseudomonas aeruginosa.Conclusions Drug resistance and infection of Pseudomonas aeruginosa became more serious than before.Resistance surveillance,based on susceptibility of rational use of effective antibiotics should be strengthened,inorder to prenvent cross infections and reduce the Pseudomonas aeruginosa producing and spreading.