Efficacy of lower dose mifepristone in treating dysfunctional uterine bleeding in perimenopausal period

Objective: To investigate the efficacy of mifepristone in treating dysfunctional uterine bleeding in perimenopausal period. Methods: 82 patients with dysfunctional uterine bleeding in perimenopausal period were treated with 6.25 mg mifepristone daily for 3 months. Effects of mifepristone on inducing amenorrhea, the changes of endocrine and the pathology of endometrium were observed before treatment and after 1, 2, 3 and 6 months treatment. Results: All patients were amenorrhea during treatment with mifepristone. Serum estradiol (E2), progestone (P) and prolactin (PRL) level showed significantly decreased after treatment (P0.05). No significant changes of serum follicle-stimulating hormone (FSH) and luteotrophic hormone (LH) levels were found after 6 months treatment. The endometrium were atrophied and anemia was improved in patients after treatment. Conclusion: Treatment of lower dose mifepristone (6.25 mg, daily) is a safe and effective method for treating dysfunctional uterine bleeding in preimenopausal period.