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A Study on Expression of CD44v6, p53, and PCNA Protein in Non-small Cell Lung Cancer

Gui Song

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Abstract

Objective To study the relationship between the expression of CD44v6, p53, PCNA protein and the clinical pathological characteristics of non small cell lung cancer (NSCLC). Methods Expression of CD44v6, p53, PCNA protein was detected in 74 NSCLC samples by immunohistochemistry. Results The positive rate of CD44v6 expression was significantly higher in NSCLC with lymph node metastasis 63.3% than that without lymph node metastasis 31.8% and PTNM stage ( P 0.05 ). The positive rate of p53 in well cell differentiation group ( 28.6% ) was significantly higher than that in poor differentiation group ( 57.4% ) and PTNM stage ( P 0.05 ).PCNA staining intensity index (SII) indicated close relationship between cell differentiation, lymph node metastasis and PTNM stage of NSCLC ( P 0.05 ).Conclusion Overexpression of CD44v6, p53 and PCNA may be relative prognosis of the patient with NSCLC, and to predict metastasis and prognosis of NSCLC.

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What this paper is about

Objective To study the relationship between the expression of CD44v6, p53, PCNA protein and the clinical pathological characteristics of non small cell lung cancer (NSCLC). Methods Expression of CD44v6, p53, PCNA protein was detected in 74 NSCLC samples by immunohistochemistry. Results The positive rate of CD44v6 expression was significantly higher in NSCLC with lymph node metastasis 63.3% than that without lymph node metastasis 31.8% and PTNM stage ( P 0.05 ). The positive rate of p53 in well cell differentiation group ( 28.6% ) was significantly higher than that in poor differentiation group ( 57.4% ) and PTNM stage ( P 0.05 ).PCNA staining intensity index (SII) indicated close relationship between cell differentiation, lymph node metastasis and PTNM stage of NSCLC ( P 0.05 ).Conclusion Overexpression of CD44v6, p53 and PCNA may be relative prognosis of the patient with NSCLC, and to predict metastasis and prognosis of NSCLC.

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Available abstract

Objective To study the relationship between the expression of CD44v6, p53, PCNA protein and the clinical pathological characteristics of non small cell lung cancer (NSCLC). Methods Expression of CD44v6, p53, PCNA protein was detected in 74 NSCLC samples by immunohistochemistry. Results The positive rate of CD44v6 expression was significantly higher in NSCLC with lymph node metastasis 63.3% than that without lymph node metastasis 31.8% and PTNM stage ( P 0.05 ). The positive rate of p53 in well cell differentiation group ( 28.6% ) was significantly higher than that in poor differentiation group ( 57.4% ) and PTNM stage ( P 0.05 ).PCNA staining intensity index (SII) indicated close relationship between cell differentiation, lymph node metastasis and PTNM stage of NSCLC ( P 0.05 ).Conclusion Overexpression of CD44v6, p53 and PCNA may be relative prognosis of the patient with NSCLC, and to predict metastasis and prognosis of NSCLC.

Key concepts: Proliferating cell nuclear antigen, Immunohistochemistry, Stage (stratigraphy), Lung cancer, Pathological, Metastasis, Lymph node, Cell

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