Expression of PCNA、E-cad and their roles in lymph node metastasis in NSCLC

Objective To investigate the expression of proliferating cell nuclear antigen(PCNA) and E - cadherin (E - cad) in non - small cell lung cancer(NSCLC) and their relationships with clinicopathological parameters,and to explore the roles in NSCLC lymph node metastasis.Methods IHC was used to detect the expressions of PCNA and E - cad in 100 specimens of patients with NSCLC and 16 specimens of adjacent normal tissues.Results The expression of PCNA was significandy higher in NSCLC than that in adjacent normal tissues(P 0.05).PCNA staining in NSCLC tissues was correlated to differentiation,TNM stage and lymph node metastasis(P 0.05).While E -cad expression was significantly lower in NSCLC than that in adjacent normal tissues(P 0.05).E - cad staining was correlated to Ivmph node metastasis and TNM stage(P 0.05 I,but not to differentiation(P 0.05).PCNA expression was negatively correlated to E - cad expression(P 0.05).Conclusion A close correlation is found between PCNA、E - cad expression and lymph node metastasis.PCNA and E -cad may play important roles in metastasis of NSCLC.