2012Hebei ke-ji daxue xuebaoOpen access

Synthesis of 4-(4-methylphenoxy) benzylamine

Mingming Chen

Open full text 0 citations

Abstract

4-(4-methylphenoxy)benzylamine was synthesized by the reaction of etherification and reduction with the starting materials of p-chlorobenzonitrile and p-cresol.The target compound was identified by IR and NMR.The total yield of the title compound is 69.3%,which is obtained under optimized conditions: n(NaBH4)∶n(BF3-Et2O)∶n(4-(4-methylphenoxy) benzonitrile)=1.2∶1.0∶1.0,reaction temperature of reflux condition and reaction time of 18 h.The present method has the advantages of availability of starting materials,mild reaction condition,convenient manipulation,non-special equipment and good yield.

About this research paper

What this paper is about

4-(4-methylphenoxy)benzylamine was synthesized by the reaction of etherification and reduction with the starting materials of p-chlorobenzonitrile and p-cresol.The target compound was identified by IR and NMR.The total yield of the title compound is 69.3%,which is obtained under optimized conditions: n(NaBH4)∶n(BF3-Et2O)∶n(4-(4-methylphenoxy) benzonitrile)=1.2∶1.0∶1.0,reaction temperature of reflux condition and reaction time of 18 h.The present method has the advantages of availability of starting materials,mild reaction condition,convenient manipulation,non-special equipment and good yield.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

4-(4-methylphenoxy)benzylamine was synthesized by the reaction of etherification and reduction with the starting materials of p-chlorobenzonitrile and p-cresol.The target compound was identified by IR and NMR.The total yield of the title compound is 69.3%,which is obtained under optimized conditions: n(NaBH4)∶n(BF3-Et2O)∶n(4-(4-methylphenoxy) benzonitrile)=1.2∶1.0∶1.0,reaction temperature of reflux condition and reaction time of 18 h.The present method has the advantages of availability of starting materials,mild reaction condition,convenient manipulation,non-special equipment and good yield.

Key concepts: Benzylamine, Yield (engineering), Benzonitrile, Chemistry, Reaction conditions, Nuclear chemistry, Organic chemistry, Materials science

Related papers

Back to paper searchBrowse research topicsOriginal source
Synthesis of 4-(4-methylphenoxy) benzylamine — Research Paper | ScholarLens