Study on the correlation of bone metabolism markers and osteoporosis

Objective To investigate the clinical significance of bone metabolism markers in patients with osteoporosis.Methods Bone mineral densities(BMD) of vertebral column and femur were measured by double functional X-ray digital bone density meter.A total of 74 patients were classified into 3 groups according to BMD: normal control(19 cases),bone-mass-reduction(25 cases) and osteoporosis(30 cases).Serum parathyroid hormone(PTH),beta-Crosslaps(β-CTX),osteocalcin(N-MID) and 25-OH Vitamin D3 levels were detected by electrochemiluminescence immunoassay.Results β-CTX and N-MID levels of osteoporosis group were significantly higher than those of normal control group and bone-mass-reduction group,and the difference had statistical significance(P0.05).PTH and 25-OH Vitamin D3 levels had no statistical significance among the 3 groups(P0.05).Conclusions There is a close relationship between bone metabolism markers and osteoporosis.Serum bone turnover markers of β-CTX and N-MID are good indicators in the diagnosis of osteoporosis and fracture risk prediction.