Relationship research of biochemical marker of bone turnover and bone mineral density in type 2 diabetes patients

Objective To investigate the clinical value of biochemical marker of bone turnover in type2 diabetes combined osteoporosis,and to find the relationship between biochemical marker of bone turnover and bone mineral density.Methods 64 cases adult males with type 2 diabetes and 20 cases healthy adult males were collected.The bone mineral density of lumbar vertebrae(L1-L4) and light huckle of all the subjects were measured by dual-energy X—ray absorptiometry.The patients were divided into osteoporosis group,osteopenia group and non— osteoporosis group according to the WHO diagnostic criteria of osteoporosis.The levels of osteocalcin(OC),procollagen type I N-terminal propeptide(PINP),β-carboxy-tenninal collagen crosslinks(β-CTX),calcium(Ca),phosphorus(P),parathyroid hormone(PTH),25-hydroxy vitamin D_3[25(OH)D_3],fasting blood-glucose(FBG).hemoglobin AlC(HbA1C),alkaline phosphatase(ALP) and serum creatinine(SCr) were detected.The results were analyzed statistically.Results There were no statistical significance in the differences of age and body mass index among all the groups(Pall 0.05).The bone mineral density levels of lumbar vertebrae(L1— L4) and light huckle in osteoporosis group and osteopenia group were all lower than that of control group,and the differences all had statistical significance(Pall 0.05).There were statistical significance in the differences of β-CTX,SCr,HbA1 C and FBG levels between osteopenia group and control group(Pall 0.05).There were statistical significance in the differences of SCr,ALP,FBG,HbA1 C,PINP,β-CTX and PTH levels between osteoporosis group and control group(Pall 0.05).The levels of 25(OH)D_3 in osteopenia group and osteoporosis group were all lower than that of control group,and the differences all had statistical significance(Pall 0.05).Correlation analysis results showed that both PINP and β-CTX were negatively correlated with the bone mineral density of greater trochanter and femur(Fall 0.05).Conclusion Combined bone mineral density and biochemical marker of bone turnover detecting can reflect bone turnover condition of diabetes patients and which is helpful for clinical judgment of the bone loss speed and early diagnosis of osteoporosis.