2012•Journal of Tongji UniversityRequires access
Detection of VEGF in patients with colorectal cancer and its clinical significance
Dong Jian
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Abstract
Objective To investigate serum levels of vascular endothelial growth factor(VEGF) in patients with colorectal cancer and its clinical significance.Methods Serum VEGF levels were detected by enzyme-linked immunosorbent assay(ELISA) in 64 patients with colorectal cancer 48healthy subjects.Results The serum VEGF levels of colorectal cancer patients were higher than those of healthy controls(t=34.11,P0.05).Among patients with colorectal cancer serum VEGF levels in those with lymph node metastasis were higher than those without lymph node metastasis(P0.05);VEGF levels in those with liver metastasis were higher than those without liver metastasis(P0.05);and VEGF levels in patients with TNM stage Ⅰ,Ⅱ,Ⅲ and Ⅳ were(120.14±25.88),(192.07±26.95),(77.93±63.18)and(433.40±48.39)pg/ml,respectively(F=83.11,P0.05).Conclusion Serum VEGF levels are increased in patients with colorectal cancer and related to lymph node metastasis,liver metastasis and TNM stages,indicating it might be used as a biomarker for colorectal cancer.