Effect of Astragalus on Expression of Urotensin II and Collagen in Renal Tissues of Rats with Heart Failure

Objective:To observe the effect of Astragalus shrink narrow induced chronic stress expression of Urotensin Ⅱ and collagen in renal tissue of overload in rats on abdominal aorta.Methods:Forty male Sprague-Dawley( SD) rats weighing 200 ~ 220 g were used.Randomly selected 10 rats in sham operation group( group Sham),the remaining 30 making coarctation of abdominal aorta model,were randomly divided into model group( group Model),Astragalus group( group Atragalus) and the Maher Bbe Chatain group( Irbesartan group),10 rats in each group.The rats in 24 h after operation administration,continuous administration for 12 weeks,records of body weight,and serum urea nitrogen( BUN),creatinine( Scr),and 24 h urinary protein;rats were killed,taken by HE and Masson in renal tissue staining of renal interstitial pathological changes,the immunohistochemical method was used to observe the expression of UrotensinⅡ,collagen Ⅰ,Ⅲ in renal tissues.Results:( 1) As compared with Sham group,Model group rats at the end of the 12 week,24 h urinary protein,serum BUN,Scr levels were significantly higher( P 0.01);the index in Model group compared with Astragalus group and Irbesartan group,there was decreased( P 0.05).( 2) Compared with Model group,in Astragalus group and Irbesartan group,renal tubular degeneration,necrosis was significantly reduced,the basic structure of integrity,interstitial collagen deposition reduction.( 3) Compared with group Sham,in renal tissue of Model group,U Ⅱ,collagen Ⅱ,Ⅲ expression increased;compared with Model group,significantly lower U Ⅱ,collagen Ⅰ,Ⅲ expression in renal tissue of Astragalus group and Irbesartan group.Conclusion:Astragalus membranaceus may through the decreasing over expression of U Ⅱ and the collagen Ⅰ,Ⅲ in renal interstitial,delaying chronic pressure overload rat renal tubulointerstitial fibrosis,and played a role in renal protection.