Effects of salusin-β on heart ischemia-reperfusion injury

AIM: To investigate whether salusin-β,a new regulatory peptide relevant to the cardiovascular system,can alleviate heart ischemia-reperfusion injury.METHODS: The effects of salusin-β on heart rate(HR),coronary flow(CF) and heart function(LVSP,LVEDP and ±dp/dt) were observed in isolated rat hearts after ischemia-reperfusion.RESULTS: Treatment with 10-8 mol/L salusin-β significantly improved the post-ischemic CF,LVDP,LVEDP and ±dp/dt compared with those of the untreated hearts.The recovery of CF,LVDP,+dp/dt and dp/dt after reperfusion for 30 min was,respectively,(52±5)%,(79±8)%,(70±8)% and(69±10)% vs.(45±6)%,(68±10)%,(58±11)% and(57±8)% in control group(P0.01,n=8).In addition,in the presence of 10-8 mol/L salusin-β,LVEDP(28.25±7.62) mmHg improved significantly compared with that in control group(52.52±11.27) mmHg.CONCLUSION: These results show that salusin-β alleviates ischemia-reperfusion injury and improves heart function.