The effect of Intermedin 1-47 on cardiac function in rats with ischemic myocardium

Objective To study the effect of intermedin 1-47 on cardiac function in isoproterenol induced myocardial injury in rats and ischemia/reperfusion(I/R) in isolated rat hearts.Mothod The myocardial Injury model was induced by isoproterenol in rats and ischemia/reperfusion in isolated rat heart.The mean arterial blood pressure(MBP), heart rate(HR),left ventricular systolic pressure(LVSP),diastolic pressure(LVDP),maximal velocity of increase and decrease of left ventriclar pressure(±dp/dt_(max)) was monitored on a BL-410.Results Compared with the normal control group,LVESP and MAP of the ISO group was decreased 41.1% and 19.7%,respectively,±dp/dt_(max) decreased 20% and 25.2%,respectively,LVEDP increased 517%.Compared with the ISO group,±dp/dt_(max) increased 8.7%,24%,respectively,in rats given with the treat of low-dose IMD 1-47 group(5 nmol·kg~(-1)·d~(-1)),and LVEDP decreased 52.8%.±dp/dt_(max) increased 26.6% and 47.4%,respectively,LVEDP decreased 67% in rats given high dose IMD 1-47 group(20 nmol·kg~(-1)·d~(-1)).Cardiac I/R induced a marked inhibition of cardiac function and myocardial injury.Reperfusion with IMD 1-47 significantly ameliorated the cardiac function inhibition induced by I/R.Conclusion IMD 1-47 has cardioprotective effects against myocardial I/R injury.