Effects of The Inhibitor of JAK/STAT on the Function of Rat Hearts After Myocardial Ischemia-reperfusion

[Objective]To investigate the effects of inhibitor of JAK/STAT on heart function after myocardial ischemia-reperfusion.[Methods]Thirty-two SD rats were randomly divided into four groups: ischemia-reperfusion group(n=8), AG490 treatment group(n=8), RMP treatment group(n=8), AG490 and RMP treatment group(n=8). Working model of isolated rat heart was used. The cardiac contractile function and myocardial enzyme leakage in the coronary effluent were detected.[Results]In AG490 or RMP used alone or in combination groups, the heart rate, left ventricular systolic pressure, the maximal change of intraventricular pressure rise or decline (±dp/dt_ max) and coronary flow were significantly higher than those of ischemia-reperfusion group(P0.05 or P0.01 ); and the left ventricular end-diastolic pressure, the leakage of myocardial enzymes(lactate dehydrogenase and creatine kinase)were significantly lower than those of ischemia-reperfusion group(P0.05 or P0.01).[Conclusion]AG490 and RMP used in combination could enhance myocardial protection during myocardial injury induced by ischemia-reperfusion.