Research progress on the expression analysis and mechanism exploration of tumor metastasis suppressor gene BRMS1

Breast cancer metastasis suppressor 1(BRMS1) has been demonstrated to be an active metastasis suppressor gene, showing metastasis suppressive role in breast cancer, melanoma, nasopharyngeal carcinoma, nonsmall cell lung cancer, ovarian cancer, and etc. It has been revealed that BRMS1 protein is able to transcriptionally regulate metastasis-related genes, further to regulate multiple cell events including cell apoptosis, cell communication, tumor angiogenesis, and etc. Herein, the molecular structure, expressional regulation, biological function and metastasis suppression mechanism of BRMS1 gene are briefly reviewed.