2013•Chinese Clinical OncologyRequires access
Progress in metastasis suppressor gene BRMS1
Yang Yinlon
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Abstract
Genes that inhibit metastasis without affecting primary tumor formation at the primary site are known as metastasis suppressor gene.Breast cancer metastasis suppressor 1(BRMS1) was identified as a new metastasis suppressor gene in 2000.Documented studies have confirmed that BRMS1 is a potent metastasis suppressor in many types of tumor not limited to breast cancer.In this review,we provide an overview of its biology function,the relationships with tumor metastasis,action mechanism and clinical significance.