Mechanism of breast cancer metastasis suppressor gene 1 inhibiting tumor metastasis

Breast cancer metastasis suppressor gene 1(BRMS1) significantly reduces the invasion and metastasis of cancer cells. BRMS1 gene expression is decreased or deleted in the cells of various malignant tumors. BRMS1 gene can inhibit tumor cells invasion and metastasis by means of regulating gene transcription and protein translation by phosphoinositide signaling and nuclear factor-κB (NF-κB) signaling pathways, repairing intercellular communication and interacting with the mSin3-histone deacetylase (HDAC) complex, estrogen receptor and other proteins. BRMS1 gene may be a new target for the gene treatment of tumor metastasis. Key words: Gene, neoplasm; Tumor metastasis; Breast cancer metastasis suppressor gene 1; Inhibiting effect