Analysis of pathogenic bacteria and their drug resistance in patients with tuberculosis combined with lower respiratory infection in epidemic prevention station of Yunxi from 2010 to 2013

Objective To investigate the pathogenic bacteria distribution and their drug resistance in patients with tuberculosis combined with lower respiratory infection. Methods 1 273 cases with tuberculosis combined with lower respiratory tract infections in our epidemic prevention station from 2010 to 2013 were retrospectively analyzed. The sputum of all patients was collected, cultured, and the bacteria were isolated and analyzed. Results Total 408 pathogen strains were detected, including 185 Gram-negative bacteria(45.3%), 147 Gram-positive bacteria(36.0%) and 76 fungi(18.7%). The top 3 Gram-negative bacteria were Pseudomonas aeruginosa(17.4%), Acinetobacter baumannii(15.2%) and Klebsiella pneumonia(7.6%); the top 2 Gram-positive bacteria were Staphylococcus aureus(19.4%) and Streptococcus pneumonia(8.8%); the top fungus was Monilia albican(18.6%). 62 patients carry two kinds of pathogens, 8 patients carry three kinds of pathogens, the other carry one kind of bacteria, total positive rate of 25.9%(330 / 1273). Resistance test results showed that imipenem and amikacin could be used to effectively treat Gram-negative bacterial infections, linezolid and vancomycin could be used to effective in the treatment of Gram-positive bacterial infections. Conclusion Most bacteria in patients with tuberculosis combined lower respiratory infection show a certain resistant to many antibiotics. Therefore, the clinical treatment should base on the resistance test results.