2006•Journal of Zhengzhou UniversityRequires access
Correlation between serum soluble P-selectin, high sensitive C-reactive protein and lipids in patients with coronary heart diseases
Dang Yu-hua
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Abstract
Aim: To study the correlations between the serum soluble P-selectin (sP-selectin), high sensitive C-reactive protein (hs-CRP) and lipids in patients with coronary heart diseases (CHD).Methods:The levels of sP-selectin, hs-CRP, TC, TG, HDL-C and LDL-C were measured in 25 patients with acute myocardial infarction (group AMI), 31 patients with unstable angina pectoris (group UAP), 22 patients with stable angina pectoris (group SAP), and 20 controls.Results: sP-selectin and hs-CRP in group AMI and group UAP were significantly higher than those in group SAP and the controls,however, sP-selectin and hs-CRP were similar in group SAP and the controls. There were obvious positive correlations between TC, LDL-C and sP-selectin and hs-CRP levels in patients with CHD.Conclusion: P-selectin and hs-CRP are useful markers in the diagnosis and classification of CHD. TC and LDL-C may aggravate the systemic inflammation and activate platelet in patients with CHD.