Preparation of simvastatin orally disintegrating tablets and its quality evaluation

Objective:To study the formulation and preparation of simvastatin orally disintegrating tablets, and evaluate its quality.Methods:The formulation of orally disintegrating tablets was optimized by orthogonal ex- periment design according to disintegrating time in vitro and taste.The tablets were prepared by direct .powder com- pression technique.The properties of the tablets,such as disintegrating time in vitro and the release profile,were determined.Results:The tablets prepared by the optimal formula were disintegrated within 32 s in vitro,while 30 s in mouth.The dissolution test indicated that 95% of simvastatin dissolved from the orally disintegrating tablet in 30 min.Conclusion:The preparation and formulation described here appears promising in simvastatin orally disin- tegrating tablets with good quality.