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Study on disintegrating method for simvastatin orally disintegrating tablets

Cai Shuang-shuang

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Abstract

Objective:To evaluate three disintegrating equipments for simvastatin orally disintegrating tablet.Methods: Simvastatin orally disintegrating tablets were prepared by solid-states-dissolution technology,and three disintegrating equipments were used to detect the disintegration of orally disintegrating tablets in vitro,and also the relationship between disintegrating results:in vivo and in vitro was studied.Results:Tube inverted method has good reproducibility,in vivo-in vitro relationship and effective control of particle size,but the results of the other two methods were not so good.Conclusion: Tube inverted method is suitable for testing the disintegration of freeze-dreled orally disintegrating tablets in vitro.

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What this paper is about

Objective:To evaluate three disintegrating equipments for simvastatin orally disintegrating tablet.Methods: Simvastatin orally disintegrating tablets were prepared by solid-states-dissolution technology,and three disintegrating equipments were used to detect the disintegration of orally disintegrating tablets in vitro,and also the relationship between disintegrating results:in vivo and in vitro was studied.Results:Tube inverted method has good reproducibility,in vivo-in vitro relationship and effective control of particle size,but the results of the other two methods were not so good.Conclusion: Tube inverted method is suitable for testing the disintegration of freeze-dreled orally disintegrating tablets in vitro.

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Available abstract

Objective:To evaluate three disintegrating equipments for simvastatin orally disintegrating tablet.Methods: Simvastatin orally disintegrating tablets were prepared by solid-states-dissolution technology,and three disintegrating equipments were used to detect the disintegration of orally disintegrating tablets in vitro,and also the relationship between disintegrating results:in vivo and in vitro was studied.Results:Tube inverted method has good reproducibility,in vivo-in vitro relationship and effective control of particle size,but the results of the other two methods were not so good.Conclusion: Tube inverted method is suitable for testing the disintegration of freeze-dreled orally disintegrating tablets in vitro.

Key concepts: Simvastatin, Pharmacology, In vivo, Reproducibility, Medicine, Chromatography, Materials science, Biomedical engineering

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