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THE DETECTION OF THE PROLIFERATING CELL IN BREAST CARCINOMA

DU Qing

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Abstract

Objective:To investigate the expression of two cell cycle related proliferating cell nuclear antigen (PCNA) and Ki67 in breast carcinoma. Methods: The immunohistochemical method was used to determine the expression of PCNA and Ki67 in 60 cases of breast carcinoma. Results:(1)The positive rate of PCNA approximates to the rate of Ki67 in breast carcinoma. (2)The positive expression rates of PCNA and Ki67 varied evidently among non specific infiltrating carcinoma, specific infiltrating carcinoma and non infiltrating carcinoma. (3)With the rise in the degree of positive stain of PCNA and Ki67, the percentage of grade ⅡandⅢ breast carcinoma also rose. Conclusion: The degree of the expression of PCNA and Ki67 correlated with the types and grades of breast carcinoma.

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Objective:To investigate the expression of two cell cycle related proliferating cell nuclear antigen (PCNA) and Ki67 in breast carcinoma. Methods: The immunohistochemical method was used to determine the expression of PCNA and Ki67 in 60 cases of breast carcinoma. Results:(1)The positive rate of PCNA approximates to the rate of Ki67 in breast carcinoma. (2)The positive expression rates of PCNA and Ki67 varied evidently among non specific infiltrating carcinoma, specific infiltrating carcinoma and non infiltrating carcinoma. (3)With the rise in the degree of positive stain of PCNA and Ki67, the percentage of grade ⅡandⅢ breast carcinoma also rose. Conclusion: The degree of the expression of PCNA and Ki67 correlated with the types and grades of breast carcinoma.

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Available abstract

Objective:To investigate the expression of two cell cycle related proliferating cell nuclear antigen (PCNA) and Ki67 in breast carcinoma. Methods: The immunohistochemical method was used to determine the expression of PCNA and Ki67 in 60 cases of breast carcinoma. Results:(1)The positive rate of PCNA approximates to the rate of Ki67 in breast carcinoma. (2)The positive expression rates of PCNA and Ki67 varied evidently among non specific infiltrating carcinoma, specific infiltrating carcinoma and non infiltrating carcinoma. (3)With the rise in the degree of positive stain of PCNA and Ki67, the percentage of grade ⅡandⅢ breast carcinoma also rose. Conclusion: The degree of the expression of PCNA and Ki67 correlated with the types and grades of breast carcinoma.

Key concepts: Proliferating cell nuclear antigen, Breast carcinoma, Immunohistochemistry, Carcinoma, Pathology, Biology, Medicine, Breast cancer

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